Abstract Detail

Abstract

Currently, developing biologically active substances based on natural polymers for dermatological applications and study their properties is an emerging field. Because, nowadays 180 million people suffer from various degrees of burns and skin injuries, and this number is increasing by 28% annually in the world. There are various methods to treat skin diseases, but the most effective approach is to use biopolymers and natural polymers that mimic the structure of the human body. Considering the above we could have created, a composite based on carboxymethyl cellulose and sericine then study their properties. However, literature indicates that copolymers linked through chemical bonds exhibit more complex interactions compared to composites. That is why, we aimed to obtain copolymers based on polysaccharides and proteins then study their properties. Firstly, everyone know polysaccharides are not toxic for the body; also, protein is ingredient in raw material for organism structure. Therefore, I aimed to obtain copolymers based on carboxymethyl cellulose (Na-CMC) and sericine cross-linked through chemical bonds and study their properties. Additionally, That is why, I believe that research on scar-free treatment of skin diseases using hydrogels, films, and sponge like materials derived from natural polymers, to improve skin function, is of current, scientific, and practical importance. Considering the above, I am conducting my research in three stages. The first stage involves obtaining dialdehyde carboxymethyl cellulose (DCMC) samples with a high content of aldehyde groups and high molecular mass by oxidizing Na-CMC samples through microwave treatment. The second stage is dedicate extracting sericine from silk fibroin. The third stage focusing on obtaining DCMC/sericine graft copolymers with different masse ratio based on oxidized DCMC and sericine extracted from silk fibroin. We analyzed obtained graft copolymers based on DCMC and sericine by FTIR, NMR spectroscopy methods and studied their thermal, sorption and physic-chemical properties.

Biography

Ilkhom Goyibnazarov is a PhD student Institute of Polymer Chemistry and Physics Academy of Science of the Republic of Uzbekistan. He finished master`s degreein 2021. He has been working since 2019 at Institute of Polymer Chemistry and Physics Academy of Science of the Republic of Uzbekistan. His master`s dissertation theme “thermodynamic properties of technical and pure sodium carboxymethyl cellulose”.